Figure 1 from Lactoferrin’s Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action | Semantic Scholar (2024)

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This article focuses on a review of the existing and most up-to-date literature on the contribution of the beneficial effects of LF on the treatment of lung diseases, including asthma, viral infections, cystic fibrosis, or lung cancer, among others.

Conclusively, due to their anti-cancer effects accompanied by substantial selectivity for cancer cells and low toxicity for normal cells, HDPs have been widely recognized as possible therapeutic agents.

A novel recombinant human Lf that exhibits glycosylation profile compatible with the natural hLf for potential parenteral therapeutic applications is produced and a potential for clinical utility of this novel rhLf in patients with lung cancer is highlighted.

The results suggest that curcumin and LF may have a potentially beneficial effect, mainly when administered in combination, leading to a reduction in cancer cells’ aggressiveness.

This approach indicates that CRC is one of the most frequently diagnosed cancers and affects the intestinal tract with high clinical and epidemiologic relevance, and the potential use of bovine Lf alone or as a natural adjunct agent to increase the effectiveness and reduce the side effects of anticancer chemotherapy.

Plasmalemmal V-ATPase can be an excellent biomarker for driving treatment decisions and forecasting clinical outcomes of Lf-based anticancer strategies and future research endeavors should seek to validate this biomarker by thorough preclinical and clinical studies, as well as to develop effective methods for its detection under clinical settings.

Bovine colostrum (BC) has attracted the interest of numerous researchers investigating its anti-cancer potential in humans, and the BC pills successfully promote the regression of low-grade cervical intraepithelial neoplasia when administered intravagin*lly.

Recent developments about the biological activities of this pleiotropic glycoprotein are discussed that will reason the exploitation of its biomedical and supplementary nutritional value.

The presented results demonstrate the high antitumor potential of systems for delivery of pentacyclic triterpenoids and the development of nanocarrier-delivery systems aimed at increasing the transport capacity of bioactive compounds by enhancing their solubility, bioavailability, stability in vivo and ensuring tumor-targeting while their toxicity and risk of side effects are significantly reduced.

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By addressing the main features of L f's structure and function, the recent developments in delineating the therapeutic mechanisms of Lf and its effects on the proteins and receptors modulating apoptosis are discussed.

Lactoferrin cytotoxicity against several cancers is reported to occur in distinct ways under different conditions, namely by cell membrane disruption, apoptosis induction, cell cycle arrest, and cell immunoreaction.

This review focuses on the therapeutic effect bovine sourced lactoferrin has on various forms of cancer in various models and the benefits of 3D in vitro cell culture.

The capability of lactoferrin to exert a potent antiviral activity, through its binding to host cells and/or viral particles, and its nuclear localization strengthens the idea that lact oferrin is an important brick in the mucosal wall, effective against viral attacks and it could be usefully applied as novel strategy for treatment of viral infections.

The immunomodulatory properties of the unique multifunctional protein Lf and its N-terminus peptides are summarized.

Results establish a common mechanism of action of bLf against highly metastatic cancer cells exhibiting plasmalemmal V-ATPase and open promising perspectives for further research on the anticancer role of Lf, which ultimately will contribute to its safer and more rational application in the human therapy of these life-threatening cancers.

Current knowledge of the spectrum of activity, proposed mechanisms of action, and capacity for synergy of lactoferrin and its peptides are reviewed, including the three most studied derivatives: lactoferricin, lact oferrampin, and Lf(1–11), as well as some lactOferrin-derived variants and modified peptides.

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